Research


Our research is focused in computational systems and synthetic biology.

We use mathematical modelling, simulation and optimization to understand complex biological systems and processes.

Current research topics include:


FUNDING AGENCIES

Current projects

DYNAMO-bio

Title: DATA-DRIVEN MECHANISTIC MODELLING, UNCERTAINTY QUANTIFICATION AND OPTIMISATION IN SYSTEMS BIOLOGY

Ref:  PID2023-146275NB-C22 

Funding: project PID2023-146275NB-C22 (DYNAMO-bio) funded by MICIU/AEI/ 10.13039/501100011033 and ERDF/EU.

PI: JULIO R. BANGA. 

Project coordinated with the group of A.F. Villaverde (UVIGO).

Period: 1-Sept-2024 to 31-Aug-2027

SuperBioComp

Title: ENHANCING THE COMPUTATIONAL BIOLOGY OF MICROORGANISMS AND PLANTS WITH NEW METHODS OF ARTIFICIAL INTELLIGENCE AND SUPERCOMPUTING

Ref:  MMT24-MBG-01 

Funding: CSIC Momentum programme 2024 

PI: JULIO R. BANGA. 

Period: 1-Dec-2024 to 30-Nov-2028


Project CSIC-Momentum MMT24-MBG-01 (SuperBioComp): The funding for these actions/grants and contracts comes from the European Union's Recovery and Resilience Facility Next Generation, in the framework of the General Invitation of the Spanish Government’s public business entity Red.es to participate in talent attraction and retention programmes within Investment 4 of Component 19 of the Recovery, Transformation and Resilience Plan. 

BioDynamics

Title: DYNAMIC REGULATION ACROSS METABOLIC ENGINEERING SCALES. MULTI-MODEL INFERENCE AND DYNAMIC OPTIMALITY (BIODYNAMICS)

Ref:  PID2020-117271RB-C22 

Funding: this research has received funding from MCIN/AEI/ 10.13039/501100011033 through grant PID2020-117271RB-C22 (BIODYNAMICS) 

PI: JULIO R. BANGA. 

Project coordinated with the group of J. Picó (UPV, Valencia).

Period: 1-Sept-2021 to 31-May-2025

LARGO

Title: LARGE SCALE GLOBAL OPTIMIZATION IN SYSTEMS BIOLOGY (LarGO)

Ref.: CSIC PIE 202470E108 

PI: JULIO R. BANGA

Period: 01-April-2024 to 31-March-2025


 

Selected completed projects (2010-present)

[MOEBIUS] Ensemble modelling in systems biology - from identification to uncertainty quantification in predictions and structure. Funded by CSIC project PIE 202070E062. 01-April-2020 to 31-May-2023


[DAOBIO] Design, analysis and optimization of biochemical pathways and genetic regulatory networks using stochastic models (DAOBIO). Funded by CSIC project PIE 202070E036. 01-Feb-2020 to 31-May-2023.


[CANPATHPRO] A platform for predictive cancer pathway modelling. Funded by the EU H2020 ITN project ref. 675585. March 2016 - Nov. 2021. CanPathPro Web


[SYMBIOSYS] Systematic models for biological systems engineering training network. Marie-Curie ITN Network, funded by the EU H2020 ITN project ref. 675585. Sept. 2015 - Aug. 2019.


[SYNBIOCONTROL] Design, characterization and optimal tuning of synthetic biocircuits for bioproduction with control of the metabolic load. Funded by the Spanish Gov., MINECO project ref. DPI2017-82896-C2-2-R. Jan. 2018 - Dec. 2020.


[SYNBIOFACTORY] Synthetic biology to improve bioprocesses: design, optimization, monitoring and control. Funded by the Spanish Gov., MINECO project ref. DPI2014-55276-C5-2-R. Jan. 2015 - Dec 2017.


[BIOPREDYN] From data to models: new bioinformatics methods and tools for data-driven predictive dynamic modelling in biotechnological applications. Funded by EU FP7, project ref. 289434. Oct. 2011 - March 2015.


[NICHE] Network for integrated cellular homeostasis. Marie-Curie ITN Network, funded by EU FP7, project ref. 289384. Jan. 2011 - Dec. 2015.


[BASYSBIO] Towards an understanding of dynamic transcriptional regulation at global scale in bacteria: a systems biology approach. Funded by EU FP6, project ref. 037469. Nov. 2006 - Apr. 2011.


List of older projects can be obtained upon request.


We acknowledge CESGA (www.cesga.es) in Santiago de Compostela (Spain) for providing us with access to its high-performance computing facilities.