Our research is focused in computational systems and synthetic biology.
We use mathematical modelling, simulation and optimization to understand complex biological systems and processes.
Current research topics include:
Reverse engineering: systems identification (dynamic modelling) of biological networks
Forward engineering: computer-aided design in synthetic biology
Optimality principles in biological systems
Dynamics and optimal control of biosystems
Title: DYNAMIC REGULATION ACROSS METABOLIC ENGINEERING SCALES. MULTI-MODEL INFERENCE AND DYNAMIC OPTIMALITY (BIODYNAMICS)
Funding: this research has received funding from MCIN/AEI/ 10.13039/501100011033 through grant PID2020-117271RB-C22 (BIODYNAMICS)
PI: JULIO R. BANGA.
Project coordinated with the group of J. Picó (UPV, Valencia).
Period: 1-Sept-2021 to 31-Aug-2024
Title: Ensemble modelling in systems biology - from identification to uncertainty quantification in predictions and structure (MOEBIUS)
Ref.: CSIC PIE 202070E062
PI: JULIO R. BANGA
Period: 01-April-2020 to 31-March-2023
Title: Design, analysis and optimization of biochemical pathways and genetic regulatory networks using stochastic models (DAOBIO)
Ref.: CSIC PIE 202070E036
PI: JULIO R. BANGA
Period: 01-Feb-2020 to 31-Jan-2023
Selected completed projects (2010-present)
[CANPATHPRO] A platform for predictive cancer pathway modelling. Funded by the EU H2020 ITN project ref. 675585. March 2016 - Nov. 2021. CanPathPro Web
[SYMBIOSYS] Systematic models for biological systems engineering training network. Marie-Curie ITN Network, funded by the EU H2020 ITN project ref. 675585. Sept. 2015 - Aug. 2019.
[SYNBIOCONTROL] Design, characterization and optimal tuning of synthetic biocircuits for bioproduction with control of the metabolic load. Funded by the Spanish Gov., MINECO project ref. DPI2017-82896-C2-2-R. Jan. 2018 - Dec. 2020.
[SYNBIOFACTORY] Synthetic biology to improve bioprocesses: design, optimization, monitoring and control. Funded by the Spanish Gov., MINECO project ref. DPI2014-55276-C5-2-R. Jan. 2015 - Dec 2017.
[BIOPREDYN] From data to models: new bioinformatics methods and tools for data-driven predictive dynamic modelling in biotechnological applications. Funded by EU FP7, project ref. 289434. Oct. 2011 - March 2015.
[NICHE] Network for integrated cellular homeostasis. Marie-Curie ITN Network, funded by EU FP7, project ref. 289384. Jan. 2011 - Dec. 2015.
[BASYSBIO] Towards an understanding of dynamic transcriptional regulation at global scale in bacteria: a systems biology approach. Funded by EU FP6, project ref. 037469. Nov. 2006 - Apr. 2011.
List of older projects can be obtained upon request.
We acknowledge CESGA (www.cesga.es) in Santiago de Compostela (Spain) for providing us with access to its high-performance computing facilities.